A Table of all published EWAS with deep molecular phenotypes (omics)

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The number of genome-wide association studies (GWAS) with deep molecular phenotypes, especially metabolomics and proteomics, is rapidly increasing. On other places of this blog I maintain tables of published GWAS with metabolomics (mQTLs), proteomics (pQTLs), and DNA methylation (meQTLs).

Here I extend this collection by a table of all published epigenome-wide association studies (EWAS) with metabolomics, proteomics, and any other (still to be published) deep molecular phenotypes.

You may also be interested in the EWAS atlas [follow this link], which is published here.

Should you know of any study missing here, please let me know.

ReferenceStudy Population/Cohort#Samples#CpGsOmics phenotype
Petersen et al. (Hum. Mol. Genet. 2014)German (KORA) population study181420 (excluding CpGs with genetic confounders)649 blood metabolic and lipid traits (Metabolon, Biocrates, and Numares/Lipofit platforms)
Sayols-Baixeras (Hum. Molec. Genet., 2016)REGICOR study and Framingham Offspring Study (replication)645+2542 (replication)14 (9 genes + 2 intergenic loci)Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides)
Braun et al. (Clin. Epigenet., 2017)Rotterdam Study725+760 (replication)5blood levels of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol
Nano et al. (Gastroenterology, 2017)Rotterdam Study731+719 (replication)8 (4 replicated)blood for liver enzyme levels, including gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)
Ahsan et al. (PLoS Genet., 2017)Northern Sweden Population Health Study (NSPHS)between 698 and 1033124121 protein biomarkers (Proseek immuno-assay technology)
Wahl et al. (BBA, 2018)4 cohorts3000+7 (5 sites)IgG glycosylation (24 glycans measured by UPLC, 50 by LC/MS)
Orozco et al.. (Hum. Mol. Gen., 2018)Metabolic Syndrome in Men cohort20113 clinical traits at 21 loci32 clinical traits in subcutaneous abdominal adipose tissue

(updated November 21, 2018)