A Table of all published EWAS with deep molecular phenotypes (omics)

posted in: Resources

The number of genome-wide association studies (GWAS) with deep molecular phenotypes, especially metabolomics and proteomics, is rapidly increasing. On other places of this blog I maintain tables of published GWAS with metabolomics (mQTLs), proteomics (pQTLs), and DNA methylation (meQTLs).

Here I extend this collection by a table of all published epigenome-wide association studies (EWAS) with metabolomics, proteomics, and any other (still to be published) deep molecular phenotypes.

You may also be interested in the EWAS atlas [follow this link], which is published here.

Should you know of any study missing here, please let me know.

ReferenceStudy Population/CohortNumber of SamplesCpG-Trait AssociationsOmics Phenotype
Petersen et al. (Hum. Mol. Genet. 2014)German (KORA) population study181420 (excluding CpGs with genetic confounders)649 blood metabolic and lipid traits (Metabolon, Biocrates, and Numares/Lipofit platforms)
Sayols-Baixeras (Hum. Molec. Genet., 2016)REGICOR study and Framingham Offspring Study (replication)645+2542 (replication)14 (9 genes + 2 intergenic loci)Lipid traits (total, low-density and high-density lipoprotein cholesterol, and triglycerides)
Braun et al. (Clin. Epigenet., 2017)Rotterdam Study725+760 (replication)5blood levels of triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol
Nano et al. (Gastroenterology, 2017)Rotterdam Study731+719 (replication)8 (4 replicated)blood for liver enzyme levels, including gamma-glutamyl transferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST)
Ahsan et al. (PLoS Genet., 2017)Northern Sweden Population Health Study (NSPHS)between 698 and 1033124121 protein biomarkers (Proseek immuno-assay technology)
Wahl et al. (BBA, 2018)4 cohorts3000+7 (5 sites)IgG glycosylation (24 glycans measured by UPLC, 50 by LC/MS)
Orozco et al.. (Hum. Mol. Gen., 2018)Metabolic Syndrome in Men cohort20113 clinical traits at 21 loci32 clinical traits in subcutaneous abdominal adipose tissue
Huang et al. (Epigenomics, 2018)Emory Twin Study (ETS)180 male twinsNA12 annotated smoking-related metabolites identified from a metabolome-wide association study
Tindula et al. (Environmental Epigenetics, 2019) Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) cohort81 mother-child pairs7 (after Bonferroni correction)92 metabolites measured by targeted metabolomics (SRM monitoring)
Hillary et al. (Nat. Comm., 2019)Lothian Birth Cohort 1936750 healthy older adults26 sites with the levels of 9 proteins92 protein levels from the Olink neurology panel
Huan et al. (Nat.Comm. 2019)Framingham Heart Study417092 putatively
causal CpGs for CVD traits by Mendelian randomization
CVD traits
Zaghlool et al. (Nat. Comm., 2020)German (KORA) population study and multi-ethnic QMDiab study944 + 344 (replication)98 (replicated)1123 blood circulating proteins (Somalogic aptamers)
Hillary et al. (Genome Medicine 2020), pre-print on BioRxivLothian Birth Cohort 1936876370 blood circulating protein levels (Olink inflammation panel)
Huan et al. (Epigenetics, 2020)Framingham Heart Study3565227 CpGs with 40 nearby miRNAs (cis-miR-eQTMs)283 blood circulating microRNAs (miRNA)

(updated August 02, 2020)