Here you find all published genome-wide association studies with glycomics traits (glycGWAS). If a study is missing from this list, please let me know.
You may also be interested in the Table of all GWAS with Metabolomics, the Table of all GWAS with Proteomics, the Table of all GWAS with DNA Methylation., and Table of all EWAS with deep molecular phenotypes (omics).
| Reference | Study population(s) | #Samples in study | #Glycan traits assayed | #glycQLTs and/or loci | Platform type / method |
|---|---|---|---|---|---|
| Lauc et al. (PLoS Genetics, 2010) | CROATIA- VIS and CROATIA-KORCULA | 2,705 | 15 N-glycans (DG1-DG13, FUC-A, FUC-C) | 3 loci, 8 glycQTLs | Total N-glycans released from plasma proteins (HILIC-HPLC) |
| Huffman et al. (Hum. Mol. Genet., 2011) | CROATIA- VIS, CROATIA-KORCULA, NSPHS (all European) | 3,533 | 33 N-glycans + 13 derived traits | 6 loci | Total N-glycans released from plasma proteins (HILIC-HPLC) |
| Lauc et al. (PLoS Genetics, 2013) | several European cohorts | 2,247 (UPLC) + 1,848 (MS) | 23 (IgG N-glycans + 54 derived traits) | 9 loci | IgG N-glycosylation (UPLC + MALDI-TOF MS) |
| Shen et al. (Nat.Comm., 2017) | ORCADES, CROATIA- VIS, CROATIA-KORCULA, TwinsUK | 1960 + 850 + 840 + 4479 | 23 (IgG N-glycans + derived traits) | 10 loci | IgG N-glycosylation (UPLC + MALDI-TOF MS) |
| Wahl et al. (Front. Immunol., 2018) | KORA + Leiden Longevity Study | 1,823 + 1,836 | 50 (20 on IgG1 and IgG2, 10 on IgG4) + derived traits | 16 loci | IgG glycosylation (LC–ESI-MS) |
| Sharapov et al. (Human Mol. Genet., 2019) (BioRxiv version) | Eurpoean + Arabs/Filipinos/Indians (TwinsUK, PainOR, SOCCS, QMDiab) | 3,811 | 36 N-glycans + 77 derived traits | 12 loci | Total N-glycans released from plasma proteins (HILIC-UPLC) |
| Sharapov et al. (Glycobiology, 2020) | Four studies: EPICPotsdam, PainOmics, SOCCS, SABRE | 4,802 | 36 N-glycans + 81 derived traits | 15 loci (replication study) | Total N-glycans released from plasma proteins (HILIC-UPLC) |
| Klaric et al. (Science Advances, 2020) | Four cohorts of European descent | 8,090 | 77 IgG N-glycan traits | 27 loci for 21 independent traits | IgG N-glycosylation (UPLC) |
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