A Table of all published GWAS with glycomics

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Here you find all published genome-wide association studies with glycomics traits (glycGWAS). If a study is missing from this list, please let me know. Latest addition: “Defining the genetic control of human blood plasma N-glycome using genome-wide association study” by Sharpov et al. in Human Mol. Genet.

You may also be interested in the Table of all GWAS with Metabolomics, the Table of all GWAS with Proteomics, the Table of all GWAS with DNA Methylation., and Table of all EWAS with deep molecular phenotypes (omics).

ReferenceStudy population(s)#Samples in study#Glycan traits assayed#glycQLTs and/or lociPlatform type / method
Lauc et al. (PLoS Genetics, 2010)CROATIA-
VIS and CROATIA-KORCULA
2,70515 N-glycans (DG1-DG13, FUC-A, FUC-C)3 loci, 8 glycQTLsTotal N-glycans released from plasma proteins (HILIC-HPLC)
Huffman et al. (Hum. Mol. Genet., 2011)CROATIA-
VIS, CROATIA-KORCULA, NSPHS (all European)
3,53333 N-glycans + 13 derived traits6 lociTotal N-glycans released from plasma proteins (HILIC-HPLC)
Lauc et al. (PLoS Genetics, 2013)several European cohorts2,247 (UPLC) + 1,848 (MS)23 (IgG N-glycans + 54 derived traits)9 lociIgG N-glycosylation (UPLC + MALDI-TOF MS)
Shen et al. (Nat.Comm., 2017)ORCADES, CROATIA-
VIS, CROATIA-KORCULA, TwinsUK
1960 + 850 + 840 + 447923 (IgG N-glycans + derived traits)10 lociIgG N-glycosylation (UPLC + MALDI-TOF MS)
Wahl et al. (Front. Immunol., 2018)KORA + Leiden Longevity Study1,823 + 1,83650 (20 on IgG1 and IgG2, 10 on IgG4) + derived traits16 lociIgG glycosylation (LC–ESI-MS)
Sharapov et al. (Human Mol. Genet., 2019)
(BioRxiv version)
Eurpoean + Arabs/Filipinos/Indians (TwinsUK, PainOR, SOCCS, QMDiab)3,81136 N-glycans + 77 derived traits12 lociTotal N-glycans released from plasma proteins (HILIC-UPLC)