Here you find all published genome-wide association studies with multiplexed protein traits in blood (pGWAS). If a study is missing from this list, please let me know.
This table was initially published as Supplementary Table 1 in Suhre et al. (2017) and has been updated as of February 25, 2018.
| Reference | Study population | #Samples in study | #Proteins assayed | #pQTLs reported | Platform type |
|---|---|---|---|---|---|
| Melzer et al. (PLoS Genet, 2008) | Population study | 1200 | 42 | 8 | Immuno-assay |
| Lourdusamy et al. (Hum Mol Genet, 2012) | Elderly Europeans | 96 | 778 | 60 | Aptamer-based |
| Johansson et al. (PNAS, 2013) | Two population cohorts | 1060 | 163 | 5 | Mass-spectrometry |
| Kim et al. (PLoS One, 2013) | Altzheimer's disease cohort | 521 | 132 | 28 | Immuno-assay |
| Enroth et al. (Nature Comm, 2014) | Population study | 970 | 77 | 18 | Immuno-assay |
| Kauve et al., PLoS Genet., 2014 | CSF fluid from two Altzheimer's disease cohorts | 574 | 59 | 5 | Immuno-assay for proteins relevant to Altzheimer's disease |
| Liu et al. (Mol Syst Biol, 2015) | Female twins | 113 | 342 | 18 | Mass-spectrometry |
| Deming et al. (Sci Rep, 2016) | Alzheimer cohort | 818 | 146 | 56 | Immuno-assay |
| Solomon et al. (Circ Cardiovasc Genet, 2016) | Population study | 330 | 51 | 27 | Immuno-assay for proteins implicated in cardiovascular diseases |
| Ahola-Olli et al. (Am J Hum Genet, 2017) | Population study | 8293 | 48 | 27 | Immuno-assay for cytokines and growth factors |
| Di Narzo et al. (PLoS Genet, 2017) | Inflammatory bowel disease (IBD) patients | 187 | 1128 | 41 | Aptamer-based |
| Suhre et al. (Nature Comm, 2017) | KORA and QMDiab study (Germany and Qatar) | 1335 | 1124 | 539 | Aptamer-based |
| Sasayama et al. (Hum Mol Genet, 2017) | CSF fluid from a Japanese population | 133 | 1126 | 476 | Aptamer-based |
| Folkersen et al. (PLoS Genet., 2017) | Population study | 3394 | 83 | 79 | Immuno-assay for proteins implicated in cardiovascular diseases |
| Sun et al. (Preprint on bioRxiv) | Interval study (UK blood donors) | 3301 | 2994 | 1927 | Aptamer-based |
| Yao et al., (Preprint on bioRxiv) | Framingham Heart Study | 6861 | 71 | 105 | Immuno-assay for proteins implicated in cardiovascular diseases |
| Ahsan et al. (PLoS Genet., 2017) | Population study | 1033 | 121 | 45 | Antibody-based proximity extension assay |
| Benson et al. (Circulation, 2017) | Framingham Heart Study and Malmö Diet and Cancer Study | 2180 | 1129 | 161 | Aptamer-based, array based genotyping and exome seq |
| Patin et al. (Nature Immunology, 2018) | unrelated, Western European ancestry, Milieu Intérieur cohort | 1000 | 87 | 36 | Mean fluorescence intensity (MFI), cell surface marker |
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