SNiPA – a single nucleotide polymorphisms annotator and browser

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www.snipa.org
The SNiPA Variant Browser shows variants (top), genes (center) and regulatory regions (bottom)

✶ Update ✶

SNiPA v3.2 (released March 2017)

Genome assembly: GRCh37.p13   Ensembl version: 87   1000 genomes: phase 3 version 5

SNiPA now includes more than half a million metabolite QTL associations and additionally 15,000 protein QTL associations from our 2017 proteomics GWAS. Further updates include CADD version 1.3 and updates to the most recent versions of phyloP and phastCons.

 

SNiPA – a single nucleotide polymorphisms annotator and browser

Need to transfer information from one SNP to another via LD? Use our web-server SNiPA – http://snipa.org

Linking genes and functional information to genetic variants identified by association studies remains difficult. Resources containing extensive genomic annotations are available but often not fully utilized due to heterogeneous data formats. To enhance their accessibility, we integrated many annotation datasets into a user-friendly webserver.

My favorite function is the BLOCK ANNOTATION. This feature allows you to enter a single sentinel SNP identifier, and then retrieve all information that is attached to any SNP that is in LD with the sentinel SNP. This is a great way of finding out what is known about a new GWAS hit.

Another powerful function is the REGIONAL ASSOCIATION PLOT. Enter a list of SNPs with their associated GWAS p-values for a locus, and get a fully interactive and richly annotated association plot back.

Source: SNiPA – a single nucleotide polymorphisms annotator and browser (published in Bioinformatics, 31:1334-1336, 2014)