Methylation of cg00736681 (chr8:134,615,234) near ST3GAL1 associates with the expression of 30 genes (CLC, PRSS33, PTGDR2, SLC29A1, SIGLEC8, IL5RA, ALOX15, SEMA7A, EMR4P, SMPD3, SPNS3, CYSLTR2, RP11-704M14.1, RAB44, IL1RL1, RP11-800A3.4, CEBPE, P2RY2, PIK3R6, EMR1, ADORA3, BACE2, CCR3, LGALS12, IDO1, SORD, OLIG1, CAMK1, ASB2, VSTM1). It also associates with eosinophil count and eosinophil percentage.
Click here to access the ST3GAL1 methylation network on comics
The genes that are regulated by ST3GAL1 play a role in asthma and atopic dermatitis
27 of these genes are listed in the String database. Out of these, fifteen overlap with an esophilic gene expression network associated with IgE in two distinct asthma populations (15/25, p-value=1.5E-28, red in the network below) [PubMed]. Five overlap with a network of nine genes involved in early-onset atopic dermatitis in blood and skin of pediatric patients (5/9, p-value=2.5E-6, blue in the network below) [PubMed].
You must be logged in to post a comment.