Let’s take a look at the network around this interesting biomarker.
We find four associations with DNA methylation (CpG’s) on chromosomes 1 (MSTO1), 2 (MFSD6), 4 (MTERFD1; PTDSS1), and 14 (NPC2; ISCA2) … an interesting starting point for further research on why these four sites associate with GlycA.
Why am I saying this? Read our review “Connecting the epigenome, metabolome and proteome for a deeper understanding of disease” in the Journal of Internal Medicine. The idea is that methylation of certain CpG sites is a readout for the body’s response to physiological challenge. Here are the annotations of the genes that may be regulated by these four CpG’s. Three out of the four CpG’s appear to be involved in mitochondrial function:
The two mutual best hits to the proteomics platforms Olink (CFHR5) and Somalogic (SERPIND1) are major glycoproteins … another interesting starting point for further research into what their link is to GlycA.
Now expand the network to a larger neighborhood by setting the maximum number of nodes to 60 and enjoy the richness of glycosylation related multiomics … incl. lots of N-glycosylation traits (PGP platform), IgA glycans (IgA platform), HbA1c (clinical biochemistry), and mannose (Metabolon HD2 and HD4).
Again – much to discover, interpret and hypothesize here. Enjoy!
Tip: Click on the “Export” tab in comics to get all details for the nodes and edges in the presently displayed network.
Tip: Read our paper “Fine-Mapping of the Human Blood Plasma N-Glycome onto Its Proteome” for an integration of the Somalogic and the total N-glycan data from QMDiab.