Leptin is an important hormone that regulates satiety. Here we look at the associations that we find in The Molecular Human.
The associations with the multiomics traits reflect known leptin biology
Most of the associations with leptin appear biologically plausible and are supported by the scientific literature, such as:
Click and focus on “insulin” (or use this link) to extend the network around leptin
Note the nice (partial correlation)-chain Leptin – Insulin – Pancreatic Hormone (PPY) – Glucagon, plus the (mutual best hit) association between PPY on the Somalogic platform and Hexose (H1) levels on the Biocrates platform.
Now we can ask: What associates with hexoses? by clicking on H1 (or following this link)
What we find are a number of molecules that are “orthologues” (mutal best hits) of hexose on other platforms, i.e. glucose in blood and urine measured on the Nightingale, Metablon and Chenomx platforms, and IgG-bound glycans on the two glycomics platform, and HbA1c from clinical biochemistry. The association with PLXNB2 on the Olink platform is not immediately evident and warrants further investigation.
Finally we can click and focus on HbA1c to arrive at the network displayed by comics at start-up
This network shall be discussed in a separate post – for now just note the link to diabetes and the association with TXNIP methylation, which is the strongest know EWAS for diabetes.