“The Molecular Human” – A Roadmap of Molecular Interactions Linking Multiomics Networks with Disease Endpoints.
We now have a paper describing comics … read it here on medRxiv.
Here are a few screenshots of The Molecular Human and its comics web-server:
Who (or what) is “The Molecular Human”?
The Molecular Human is a network of over 34,000 associations between over 8,700 multiomics traits and disease endpoints. The underlying associations are derived from 18 technically diverse deep molecular phenotyping (omics-)platforms analyzing urine, blood, and saliva samples from up to 374 participants of the multi-ethnic diabetes case-control study QMDiab [link to the QMDiab cohort paper].
The links between the multiomics traits include (1) partial correlations between traits from the same platform (GGMs) [ref], (2) mutual best hits for pairwise all-against-all correlations between platforms [ref], (3) genome-wide, epigenome-wide and transcriptome-wide associations with multiomics traits and disease endpoints, and (4) phenome-wide associations with QMDiab clinical traits.
What can be learned from “The Molecular Human”?
We regularly post individual analyses, insights and use-cases using The Molecular Human and its comics web-interface.
- The NLRC5 – chronic inflammation network
- Comics take on: Leptin
- Comics take on: GlycA
- Comics take on: ST3GAL1 and esosinophils
We are also in the process of writing a paper that describes The Molecular Human. Once it is ready we shall post it on MedRxiv and link it here.
Which are the omics platforms that characterized “The Molecular Human”?
The table below is the list of all platforms on which QMDiab samples have been analyzed (so far).